Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Doherty, Natural and synthetic neuroactive steroid modulators of GABA and NMDA receptors. This methyl amide 65 was shown to activate α5 subtypes in vivo in rats at low concentrations, providing a valuable tool to study the α5 GABAA receptor subtype.Recent work has shown SH-053-2'F-R-CH3 (52) and MP-III-022 (65) exert antidepressant-like effects in mice, indicating a new use for α5 subtype selective ligands. has discovered a use for α5 subtype selective ligands outside of the central nervous system.Due to the high rate of comorbidity of schizophrenia with anxiety, epilepsy and depression, the S-enatiomer (51) is shown here to be useful in these instances exhibiting anxiolytic and anticonvulsant properties.In addition, work on analogs of 52 produced MP-III-004 (63), an α5 subtype selective ligand with reduced efficacy at the α1, α2 and α3 subtypes as compared to 52, as well as the very potent α5 positive allosteric modulator MP-III-022 (65).A series of heterocyclic bioisosteres were synthesized to specifically overcome short half-lives in vivo.
Progress report on new antiepileptic drugs: a summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII). The enantiomers SH-053-2'F-S-CH3 (51) and SH-053-2'F-R-CH3 (52) have been shown to be α2/α3/α5- and α5- subtype selective agonists, respectively.Both ligands (S)-51 and (R)-52 have been shown to reduce some positive symptoms of schizophrenia; the S-enantiomer 51 was active in the poly(I: C) model of schizophrenia while the R-enantiomer 52 was active in the MAM-model of schizophrenia. Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. Martinez Botella G, Salituro FG, Harrison BL, et al.
Search for nonsedating anxiolytic:
A series of ligands based off HZ-166 (3) were synthesized.